活动

2011年7月18日

下午五时至六时

香港中文大学行政楼地下祖尧堂

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3943 8893

杨焕明教授简历

深圳华大基因研究院理事长

中国科学院院士

杨焕明教授，深圳华大基因研究院董事长，中国科学院院士，发展中国家科学院（TWAS）院士，印度科学院外籍院士，EMBO成员。

 「华大基因」为「人类基因组计划」、「人类单体型图计划」等国际合作的基因组计划，以及我国的水稻、家蚕等基因组的研究做出了重大贡献。「深圳华大」是目前世界上最大的基因组研究中心。2009年以来，和合作者在《科学》和《自然》系列等杂志上发表了「国际1000人基因组」、第一个亚洲人的基因组、人类古人类和pan-基因组、人类肠道meta-基因组以及黄瓜、大豆、玉米和大熊猫、蚂蚁等基因组、外显子组、转录组和甲基化组等「组学」的研究。

 「深圳华大」是「国际1000人基因组计划」、「国际1000种植物基因组计划」、「国际1000种动物基因组计划」、「国际10000种微生物计划」、「国际10000种脊椎动物基因组计划」和 「世界三极动物基因组计划」的主要倡议者和执行者。

讲座摘要(English version only)

"Genomics and Personalized Medicine"

2011 sees the 10th anniversary of the first publication of the draft sequence of the human genome generated by the International Human Genome Project (HGP).  With the DNA sequence in hands as the reference, we further realize that we know so little about life and ourselves. 

The HGP has cultivated a new science, GENOMICS, and opened the door to Personalized Medicine which is characterized by and based on personal genome sequencing.  Genomics will bring more knowledge about human genome variations especially the population- or even individual-specific variations and those related to diseases, about evolution of our genomes especially the adaptation-related genes, about the microorganisms in our body especially host-microbe interactions, about the motablic/ signaling pathways and genome regulation network.

Sequencing technology will reshape the whole field of biomedicine.  The application of sequencing has been extended from Southern Sequencing (whole genome/ exome sequencing, trace/single cell sequencing, targeted sequencing, …), to Northern Sequencing (whole transcriptome sequencing, digital expression profiling, micro- and all other RNAseq), Western Sequencing (translatome/ regulatome sequencing, and other CHiP+seq), to Eastern Sequencing (methylome and other epigenome sequencing), and even more.